Top 10 AI agent startups from Y Combinator's first spring Demo Day
Y Combinator's inaugural spring cohort showcased 70 AI agent startups, with 10 standout companies revolutionizing industries from healthcare to fintech.
Y Combinator's first-ever spring cohort featured 70 startups focused on agentic AI, with Demo Day showcasing their innovative technologies. The intensive three-month accelerator program invests $500,000 in each selected startup, continuing YC's legacy of nurturing successful companies like Stripe, Airbnb, and Instacart.
Key Highlights:
- 70 of 144 startups in the spring 2025 batch build AI agents
- YC partners prioritized creative applications of AI across industries
- Startups span healthcare, fintech, cybersecurity, and robotics
Top 10 AI Agent Startups:
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Aegis
- Focus: Automates insurance appeals for healthcare providers
- Founders: Krishang Todi, Aarav Bajaj, Dhanya Shah
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Airweave
- Focus: Turns productivity tools into searchable AI agent databases
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Approval AI
- Focus: Automates mortgage processes from rate shopping to paperwork
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Atlog
- Focus: AI voice agents for furniture rental sales calls
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Beluga Labs
- Focus: Financial organization for content creators
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Casco
- Focus: Simulates attacks on AI systems to find vulnerabilities
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Galen AI
- Focus: Personalized health advice from wellness data
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Mbodi AI
- Focus: Teaches new skills to existing robots
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Plexe
- Focus: Open-source agents for predictive ML models
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Willow
- Focus: Voice dictation with tone-matching AI
For more on AI startups, see Business Insider's coverage.
The spring 2025 batch marks Y Combinator's expansion to two annual cohorts, with a clear emphasis on practical AI applications across diverse sectors.
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About the Author
Dr. Emily Wang
AI Product Strategy Expert
Former Google AI Product Manager with 10 years of experience in AI product development and strategy formulation. Led multiple successful AI products from 0 to 1 development process, now provides product strategy consulting for AI startups while writing AI product analysis articles for various tech media outlets.